幹細胞外泌體結合3D生物列印GelMA材料對STZ誘導糖尿病大鼠之傷口癒合影響

Effect of stem-cell-exosome-embedded GelMA hydrogel fabricated by 3D bioprinting on wound healing in streptozotocin-induced diabetic rats

許至廷(Chih-Tim Hsu)

指導教授 ： 郭柏齡

共同指導教授 ： 曾宇鳳(Yufeng Jane Tseng)

國立臺灣大學/電機資訊學院/生醫電子與資訊學研究所/碩士(2021年)

https://doi.org/10.6342/NTU202100407

摘要

細胞治療的興起也帶動了大家對細胞外泌體治療的關注，近幾年來間質幹細胞在細胞治療中已表現出免疫調節的能力和治療的能力，而這些本領被許多人認為是來自間質幹細胞所分泌出的外泌體。然而想將這些外泌體散佈到傷口上被眾人所低估，因此本研究嘗試用水凝膠將外泌體可以送至傷口，而這水凝膠是可以客製化並應用在各種不同的臨床需求，我們希望這種傷口貼布設計可以在未來對傷患有所幫助。

關鍵字

間質幹細胞外泌體 ； 甲基丙烯酰基明膠 ； 傷口貼布 ； 3D 列印 ； 傷口癒 合

並列摘要

With the rise of cell therapy, exosome therapy had also gained many attentions in the field of biomedical engineering. In recent years, mesenchymal stem cells have been shown to possess immunomodulation and regeneration abilities in cell therapy. It was believed that these capabilities came from their own exosomes. However, the most optimal way of delivering exosomes to the wound site had been underrated. Therefore, experiments were conducted in this study to deliver exosomes to the wound with the help of hydrogels, which can be fabricated on customization and applied to literally any shape of wound. We hope that the dressings designed could be utilized in clinical use in the near future for patients in need

並列關鍵字

Mesenchymal stem cells Exosomes ； GelMA hydrogel ； healing patch ； 3D printing ； wound healing

參考文獻

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