This study examines the relationship between job security and turnover among Generation Z (Gen Z) professionals in Vietnam, noting the mediating roles of three mediators, including effective commitment, emotional exhaustion, and job satisfaction. Data was collected from 624 respondents across industries in Vietnam through an online survey. This study employs the partial least square structural equation modeling (PLS-SEM) method using Smart PLS 4.0 software for data analysis. Results demonstrate that while job security itself did not directly reduce turnover intention significantly as expected, emotional exhaustion and job satisfaction played as significant mediators in the relationship between job security and turnover intention. Affective commitment, however, did not show a significant mediating effect in this context. Besides, the mediating role of job satisfaction is significant in the relationship between emotional exhaustion and turnover intention. The findings suggest that while job security may not directly reduce turnover intention or be mediated by affective commitment, it does influence turnover intention indirectly through mediators, including emotional exhaustion and job satisfaction. These insights can inform strategies for managing turnover and enhancing retention among Gen Z employees in organizational settings.