The crossing Number $cr(G)$ of a graph $G$ is the smallest crossing number among all drawings of $G$ in the plane. In this paper, we determine the crossing number of the tripartite graph $K_{2,4,n}$ for any integer $n$. Our proof depends on Kleitman's results for the complete bipartite graphs. At last, we propose a conjecture of the crossing number of $K_{2,m,n}$.