- 學位論文
抗麩質抗體在自體免疫疾病中之免疫球蛋白A 的表現
Anti-gliadin IgA antibody in patient with autoimmune disease
摘要
目的: 腹腔性疾病(Celiac disease)主要是一種具很強的遺傳特質，即由於身體免疫系統對麩質(gliadin)產生過敏而導致小腸發炎，近期一些報導顯示， 腹腔性疾病與其他的自體免疫性疾病有關連，病人具有自體免疫性疾病和帶有抗麩質抗體的相關性我們將會在本文中討論。 材料與方法: 我們收集了一些自體免疫性疾病病人血清以酵素免疫分析法(ELISA)來測其抗麩質IgA的抗體，這些病人包括乾燥症(Sjogren’s syndrome)126位，全身性紅斑性狼瘡(Systemic lupus erythematosus)84位，類風濕性關節炎(Rheumatoid arthritis )42位，糖尿病(Diabetes mellitus)42位，貧血(Anemia)35位，僵直性脊椎炎(Ankylosing spondylitis )42位，C型肝炎(Hepatitis C virus )42位和27為健康者之血清。 結果: 實驗結果顯示，結果發現總共55位病人帶有anti-gliadin IgA抗體，其中126位乾燥症候群病人，有12位(9.52%)帶有anti-gliadin IgA抗體，84位全身性紅斑性狼瘡病人，有21位(25%)帶有anti-gliadin IgA抗體，35位貧血病人，有3位(8.57%)帶有anti-gliadin IgA抗體，42位糖尿病病人，有6位(14.3%)帶有anti-gliadin IgA抗體，42位僵直性脊椎炎病人，有3位(7.1%)帶有anti-gliadin IgA抗體，42位C型肝炎病人，有9位(21.43%)帶有anti-gliadin IgA抗體，27位健康者，有1位(3.7%)帶有anti-gliadin IgA抗體。 結論: 結果顯示anti-gliadin IgA抗體在全身性紅斑性狼瘡病人血清中，其陽性率大於其它的自體免疫性疾病病人血清，腹腔性疾病與其它自體免疫性疾病的相關性，我們將更進一步深入探討。
並列摘要
OBJECTIVE: Celiac disease(CD) is a inflammatory enteropathy induced by gliadin in genetically susceptible individuals. Recent report showed link between CD and other autoimmune disease .The relationship between anti-gliadin antibody and patients with autoimmune disease were estimated in the study. METHODS: The antigen of gliadin were tested in patients with autoimmune disease by enzyme-linked immusorbent assay(ELISA).The sera sample were consisted of 126 patients with Sjogren’s syndrome(SS),and 84 patients with Systemic lupus erythematosus(SLE),42 patients with Rheumatoid arthritis,42 patients with Diabetes mellitus , 42 patients with Ankylosing spondylitis , 42 patients with Hepatitis C virus and35 patients with Anemia. The 27 serum of health group were also obtained. Results: In analysis of anti-gliadin IgA antibody,12(9.52%)of 126 patient serums with SS,21(25%)of 84 patient serums with SLE,1(2.38%) of 42 patient serums with RA,6(14.3%)of42patient serums withDM,3(8.57%)of 35 patient serums with Anemia, 3(7.1%)of42patient serums with AS, 9(21.43%)of42patient serums with HCV, 1(3.7%) of 27 the health group have antibody reacted with gliadin. Conclusions: Our result shows that the patients with SLE were higher anti-gliadin antibody than patients with other autoimmune disease. The relationship between the patient s with CD and other autoimmune disease should be estimated in the future.