- 學位論文
洋車前子殼纖維介入對於心血管疾病風險相關之體位變化及血液生化值之探討
Effect of psyllium husk fiber on risk factor of cardiovascular disease: anthropometric data and specific biomarkers
摘要
美國膳食協會指出膳食纖維不僅有助於維護健康、預防疾病，更可當作一種醫學營養治療。已有證據顯示補充水溶性膳食纖維可有效改善心血管疾病相關指標因子及體重控制；水溶成分越高其黏稠力也隨之增加，並能有效地降低血脂濃度。洋車前子殼所含的水溶性纖維高達70%。本研究主要之目的為探討補充洋車前子殼纖維後，對於心血管疾病相關之血液生化值及體位之影響。本研究為平行、隨機及單盲試驗；並採用洋車前子殼純化粉末作為介入品，研究為期12週；招募對象為過重或肥胖者(BMI≥24)，兩組每日介入劑量皆為7公克。有效樣本洋車前子殼組17人，安慰劑組16人。結果發現：洋車前子殼纖維介入後之熱量攝取、體重、身體質量指數、腰圍周長均有顯著性減少(p <0.05)；總膽固醇與低密度脂蛋白膽固醇濃度有顯著性降低(p <0.05)，高密度脂蛋白膽固醇濃度也有顯著性增加(p <0.05)。 TC/HDL-C與LDL-C/HDL-C比值則同為顯著性下降(p <0.05)。研究結論為每日補充7公克洋車前子殼纖維有助於降低體重、腰圍及身體質量指數並改善體內血膽固醇濃度；積極減重及控制血脂濃度，可能有效降低罹患心血管疾病之風險。
並列摘要
The Academy of Nutrition and Dietetics had demonstrated the benefits of dietary fiber in health maintenance, disease prevention and as a component for medical nutrition. There are evidences showed that soluble fiber might reduce the risk factors predicting cardiovascular disease and beneficial in weight control. The greater the solubility of a dietary fiber will perform greater viscosity and show a good effect in lowering serum cholesterol. Psyllium husk contains about 70% soluble fiber. The purpose of this study is to observe the effect of psyllium husk on the risk factor of cardiovascular disease: the value of biomarkers and body weight. This is a parallel, single-blinded randomized controlled trial by adding high purity psyllium husk into the normal diet of the overweight people (BMI≥24) for twelve weeks. Seventeen subjects are categorized into psyllium group and 16 subjects into placebo group while 7 gram of psyllium or placebo was included in their daily diet. Intake of psyllium for 12 weeks resulted a significant decrease in calorie intake, body weight, BMI and waist length (P<0.05); a significant decline in the level of total serum cholesterol and low-density lipoprotein cholesterol. Moreover, the level of high-density lipoprotein cholesterol was elevated (P<0.05) and the ratio of TC/HDL-C and LDL-C/HDL-C showed significant decrease (P<0.05). In conclusion, intake of 7 gram of psyllium husk will reduce the body weight, waist length and BMI and it help in controlling the level of serum cholesterol. In addition, the loss of body weight and good control of lipid profile can help in reduce the risk of cardiovascular disease.