- 學位論文
超音波導引高強度聚焦式超音波治療儀輸出功率品質保證分析
Analysis of Output Power Quality Assurance for Ultrasound-Guide High-Intensity Focused Ultrasound (HIFU) Therapy Devices
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摘要
本研究目的在於探討下置式HIFU與上置式HIFU，兩種不同高強度聚焦式超音波治療儀在肌肉組織消融效果上的差異。這兩種設備在臨床應用中，都是依賴超音波影像上的高訊號變化來導引治療，但這種依賴即時目測的方法存在不穩定及不確定性，容易出現假陰性和假陽性結果。為了解決這一問題，本研究使用這兩種設備在臨床治療條件下對豬里肌肉組織進行消融，再以核磁共振來評估傷害狀況。我們觀察到兩種儀器的輸出時間模式不同，對傷害造成的效果完全不一樣，下置式HIFU是在一秒內持續輸出造成傷害，上置式HIFU則是手動控制輸出次數，在手動輸出次數之間也會有停留的時間。從實驗結果中我們發現，消融範圍會受到擴散效應的影響，而擴散則會被時間因子影響。參數的設定是造成HIFU消融效果的最主要因素。此外，我們還注意到在實驗中使用的不同影像技術中，雖然沒有顯著的數值差異，但BRAVO序列影像在3D呈現上的優勢，使我們能更全面地觀察消融範圍的立體結構，這有助於更準確地理解消融過程中的組織反應。
並列摘要
The purpose of this study is to investigate the differences in ablation effects on muscle tissue between two different high-intensity focused ultrasound (HIFU) devices: bottom-mounted HIFU and top-mounted HIFU. Both devices rely on high signal changes in ultrasound imaging to guide treatment in clinical applications. However, this real-time visual inspection method has instability and uncertainty, which can lead to false-negative and false-positive results. To address this issue, the study used these two devices to perform ablation on porcine psoas muscle tissue under clinical treatment conditions, followed by evaluation of the damage using magnetic resonance imaging (MRI).We observed that the output time patterns of the two instruments are different, resulting in entirely different effects on the damage caused. The bottom-mounted HIFU continuously outputs damage within one second, while the top-mounted HIFU is manually controlled for the number of outputs, with intervals between manual outputs. From the experimental results, we found that the ablation area is affected by the diffusion effect, which is influenced by the time factor. The parameter settings are the main factor influencing the ablation effect of HIFU. Additionally, although there was no significant numerical difference in the different imaging techniques used in the experiment, the BRAVO sequence imaging showed an advantage in 3D presentation, allowing for a more comprehensive observation of the three-dimensional structure of the ablation area. This helps in more accurately understanding the tissue response during the ablation process.
參考文獻
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