- 學位論文
大鼠紋狀體與運動區之間的腦活動訊號關聯性的研究
A Correlation Relationship Study within EEG Activity Signals between the Striatum and the Motor Cortex in the Brains of Rats
摘要
帕金森氏症是因為大腦黑質多巴胺分泌異常導致視丘下核(STN)異常的放電，進而影響到蒼白球、皮質層(Cortex)、紋狀體(striatum)…等等，而引起一連串的病態生理變化及運動障礙的症狀。現今醫學實驗證明人類的紋狀體與運動區之間會因為多巴胺分泌量造成影響，因此這篇論文主要的研究是探討正常的大腦下兩者之間的影響與關連性是什麼。本實驗我們從大鼠的活體電訊號分析去了解人的腦電訊號兩者之間的關係，而此直接從活體測量電訊號分析的實驗是較少。基於如此，本研究實驗使用一套八通道的侵入式活體電訊號量測系統，前四通道為紋狀體電訊號，後四通道為運動區電訊號，然後利用紋狀體與運動區訊號之間的相關係數去說明他們的相關強度，目的是找出兩者在相同頻譜或不同頻譜的能量有否關連性，並根據大鼠行為分別統計這些相關係數畫出其分佈曲線去推測他們的相關強度，最後我們得到了確實運動區和紋狀體之間的訊號是有一定程度的線性相關，但是不同頻譜的相關度會比較少。
並列摘要
Parkinson's disease is a dopamine deficiency state caused due to the degradation of death in the subthalamic nucleus, leading to abnormal discharge of subthalamic nucleus (STN). Thereby affecting the globus pallidus, cortex, striatum... etc, caused a series of pathological changes and symptoms of movement disorders. Today's medical experiments show lots of studies of the striatum and motor cortex because of the impact of dopamine secretion, so we want to study further their influence and correlation. This article focuses on the correlation of the normal brain. To simulate the EEG signals from the signal analysis of rats’ brain in vivo, we make the experimental analysis directly from the measured signal in vivo is relatively small. Therefore, the experiment use a set of eight channels-invasive system to measure the EEG signals in vivo. The first four channels are used to measure the striatum signals, the other channels are used to measure the signals of the motor cortex. Then, the correlation coefficient between the striatum and motor cortex signals represents their relationship. The theme is to find the relationship between the two by their spectrum. The statistical correlation coefficients based on the behavior of the rats, and then draw a cumulative distribution curve to prove their relevance. Finally, we get the signals between the motor cortex and striatum have a certain degree of linear dependence. However, the different spectrum will be relatively small.