乙基纖維素水性擬乳膠之薄膜特性

Properties of Aqueous Ethylcellulose Pseudolatex Membranes

黃偉峰(Wei-Fung Huang)

指導教授 ： 孫一明

元智大學/工程學院/化學工程與材料科學學系/碩士(1996年)

摘要

本研究利用噴霧包覆與溶鑄法的技術，製造水性擬乳膠液之自由薄膜，
以探討其內相關之輸送性質。其結果發現，在以噴覆法製膜時，包覆液於
高固體含量下，膜材結構中有許多孔洞性結構，當固體含量降低時，孔洞
性結構變少，固體含量約在 6﹪時可獲得較緻密的膜材。以此固體含量添
加不同比例的塑化劑 DBS ，在噴覆法所製得的薄膜，於藥物及水蒸氣滲
透實驗中，藥物與水蒸氣的滲透速率會隨著所添加塑化劑濃度的增加而降
低，但是在溶鑄法製得的薄膜中卻是相反的趨勢；在相同的塑化劑濃度下
，藥物及水蒸氣分子於噴覆法所製得的薄膜中之滲透速率皆大於溶鑄法所
製得的膜中之滲透速率。塑化劑含量的增加，也會使得薄膜的伸長量增加
，楊氏係數降低，但是抗張強度卻差別不大。同時，熱處理溫度的提高，
可使藥物及水蒸氣分子於膜中的滲透速率降低。同時比較兩種成膜法所製
得薄膜之特性，可以發現，噴覆法所製得的薄膜之楊氏係數大於溶鑄法所
製得的薄膜，伸長量小於溶鑄法所製得的薄膜，抗張強度相差不多。由以
上結果可知，噴覆法與溶鑄法具有不同的成膜機制與膜材特性。

關鍵字

薄膜 ； 薄膜包覆 ； 噴霧包覆 ； 溶鑄成膜 ； 滲透係數

並列摘要

The transport and mechanical properties of the free films of
pseudo-latex ethylcellulose prepared by spray-coating and
casting methods were studied. The porosity of a spray coated
membrane decreases as the solid content in the coating solution
decreases, and it was found that a dense membrane can be
obtained from a solution of 6% solid content within a reasonable
processing time. Dibutyl sebacate (DBS) was added in the coating
solution as a plasticizer. The permeabilities of drug or water
vapor through sprayed membranes decrease with increase
plasticizer content; in a contrast, those thuough cast membranes
increase with increasing plasticizer content. Increasing the
post thermal treating temperature resulted in water vapor
permeability decreasing in a membranes prepared by both methods.
Mechanically, the sprayed membranes were harder and more brittle
than the cast membranes of similar formulation, but membranes
prepared from both methods possessed similar breaking strength.
keywords: film coating, spra-coating, casting, membrane,
permeability.

並列關鍵字

membrane ； film coating ； spray coating ； casting ； permeability