- 學位論文
阿茲海默症患者之神經精神症狀與肌少症之探討 – 具性別差異
Neuropsychiatric symptoms and sarcopenia in Alzheimer’s disease – gender difference
摘要
背景: 阿茲海默症病人有神經精神症狀之表現。肌少症為老年症候群其中一個表現，其會增加跌倒及失能的風險。目前尚缺乏對於阿茲海默症患者神經精神症狀及肌少症相關性的研究。 研究方法: 自老年精神科門診收案，一年內共有100名年紀65歲以上阿茲海默症的患者參與本研究。肌少症的定義是根據亞洲肌少症小組於2014年所建議的準則。神經精神症狀則是使用簡短版神經精神量表(Neuropsychiatric Inventory–Questionnaire，NPI-Q)。進行兩者相關的統計分析，並探討性別差異。 結果: 參與者之平均年齡為78.1±6.1歲，男性佔32%。有肌少症的比率為31%. 男性中68.8%有肌少症，而女性僅有13.2%有肌少症。在所有受測者中，NPI-Q各分項症狀與肌少症無顯著相關。以性別分層分析，發現女性淡漠症狀之嚴重度與肌少症相關，而男性無任何神經精神症狀或神經精神症狀之嚴重度與肌少症相關。 結論: 在阿茲海默症病人中，男性有較高機會有肌少症，然神經精神症狀與肌少症相關僅發生在女性，女性淡漠症狀嚴重度與肌少症有相關。本研究發現肌少症與神經精神症狀之間有性別差異。
並列摘要
Background: Neuropsychiatric symptoms (NPS) are common among patients with Alzheimer’s disease (AD). Sarcopenia is one of geriatric syndromes, which possibly leads to higher falling rate and increased risks of disability. The relationship between NPS and sacropenia is still unclear. Methods: Study participants were 100 patients with AD aged 65 or older from geriatric psychiatric outpatients in one-year study period. Sarcopenia was defined according to the consensus of Asian Working Group for Sarcopenia in 2014. NPS were assessed using the Neuropsychiatric Inventory–Questionnaire (NPI-Q). Association between NPS and sarcopenia would be performed. The difference of association by gender would be further conducted. Results: The mean age was 78.1±6.1 years and 32% were male. Rate of sarcopenia was 32%. 68.8% of male AD were sacropenia, whereas 13.2% of female were sacropenia. There was no significant association between any symptoms of NPS and sacropenia among all participants. If analyses performed by gender stratification, we found the severity of apathy was associated with sacropenia in female, whereas none specific NPS findings in male. Conclusions: This study found that sarcopenia was more likely among male patients with AD than female. However, the association between NPS and sarcopenia was only seen in female. The severity of apathy was associated with sacropenia in female AD. There was gender difference in association between NPS and sacropenia.