- 學位論文
內側前額葉涉及情緒記憶之歷程
Medial Prefrontal Cortex is Involved in the Process of Emotional Memory
摘要
研究證據指出，大腦的內側前額葉（medial prefrontal cortex , MPFC）可能涉及對杏仁核激發狀態的相關調控，進而影響情緒記憶的形成、儲存與提取等歷程。本研究之目的在於瞭解MPFC涉及到情感性學習之功能。實驗一讓大鼠進行單次被動逃避學習作業的訓練，在訓練後24小時以通入電流的方式破壞MPFC，並且在一週恢復期之後檢測其情緒記憶之表現。實驗二則是在訓練前以相同方式破壞MPFC，讓大鼠進行單次被動逃避學習作業的訓練，並且分別在兩個不同的時間點：訓練後2小時/訓練後24小時，檢測其短期/長期情緒記憶之表現。本研究結果顯示，破壞MPFC會損害到訓練後24小時在被動逃避作業所檢測之長期記憶表現，但是並未損害到訓練後2小時的短期記憶表現。即使接受促發處理也無法改善長期記憶受損之情形。因此，本研究推論MPFC並未涉及大鼠對於被動逃避作業的記憶獲得與提取歷程，而是影響到將短期記憶轉為長期記憶儲存之固化歷程。
並列摘要
Evidences show that medial prefrontal cortex (MPFC) may be involved in modulating activities in amygdala. Further, it affects the process of forming, storing and retrieval of emotional memory. The purpose of our research is to determine the function of MPFC involved in affective learning. In experiment 1, the rats were trained to learn one trial passive avoidance task（PA task）The MPFC were electrically lesioned after 24 hours. They were tested for their affective memory after a week of recuperative period. In experiment 2, the rats were relearned and they were tested at two time points: 2hr and 24hr respectively. Our experiments showed that MPFC lesioning impaired 24 hours retention test, but not 2 hours retention test, in PA learning. The priming procedures could not improve the MPFC lesioned rats in PA task. Our experiments suggest that MPFC is not involved in the acquisition and retrieval process of emotional memory, but has an impact on the consolidation process that short-term memory converted to long-term memory for storage.