在水中利用鈀催化苯胺類與烯丙醇類化合物進行烯丙基化反應的研究

Palladium-Catalyzed Allylation of Anilines Using Allylic Alcohols in Water

徐儀君(Yi-Chun Hsu)

指導教授 ： 楊世群

高雄醫學大學/藥學院/藥學研究所/碩士(2005年)

摘要

有機金屬化學最主要的目的就是藉著使用配位基以共價鍵的形式結合過渡金屬當作催化劑來合成有機化合物。其中鈀催化親核性試劑進行烯丙基化反應是相當有效且簡便的方法，並且廣泛地應用在有機合成上。
在水中進行有機反應最近非常受到矚目，不只是因為其獨特性也因為水安全無毒，有取代有機溶媒的經濟價值。因此，環境安全的發展，以及在水中進行原子經濟反應是合成化學上重要目標之ㄧ。
在本研究中，我們完成了在水中利用鈀催化苯胺類與烯丙醇類化合物並加入催化量的酸進行烯丙基化反應的研究。

關鍵字

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並列摘要

A principal goal of organometallic chemistry is the catalytic synthesis of organic compounds by using the distinct reaction chemistry of organic ligands covalently bound to transition metals. The palladium-catalyzed allylation of nucleophiles is an established and efficient method, which has been widely applied to organic chemistry.
Organic reaction in water have recently attracted much attention, not only because of its unique reactivity is often observed in water but also because water is a safe and more economic solvent for conventional organic reaction. Thus, the development of environmental safe, atom-economical reactions in water is one of the most important goals of synthetic chemistry.
In this study, we carried out the allylation of anilines with allylic alcohols in water in the presence of palladium as catalyst. A catalytic amount of carboxylic acid was needed as additive during the reaction.

並列關鍵字

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參考文獻

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