- 學位論文
Flunitrazepam導致複雜性睡眠行為的盛行率與臨床相關因素研究
Prevalence and Clinical Correlates of Flunitrazepam-Related Complex Sleep Behaviors
摘要
目的：複雜性睡眠行為常與安眠鎮靜藥物使用有關，本研究旨在探討精神科門診個案服用flunitrazepam導致複雜性睡眠行為的盛行率與臨床相關因素。 方法：本研究從100年6月至101年5月於精神科門診邀請268位服用flunitrazepam至少3個月以上之個案加入，調查個案是否發生複雜性睡眠行為、人口統計學資料、flunitrazepam藥物劑量及服用時間長短、精神科疾病診斷、生理疾病及酒精使用等資料，並用邏輯迴歸分析檢驗複雜性睡眠行為之相關因素。 結果：66位個案曾出現複雜性睡眠行為，盛行率為24.6%，邏輯迴歸分析顯示：flunitrzepam每日服用藥物劑量大於2毫克(odds ratio [OR] = 1.941, 95% confidence interval [CI] = 1.090-3.455, p = .024)及酒精使用(OR = 1.948, 95% CI = 1.023-3.709, p = .042)與複雜性睡眠行為發生達統計學上顯著相關，而性別、年齡、flunitrazepam服用時間長短、精神科疾病診斷、生理疾病則未與複雜性睡眠行為達顯著相關。 結論：服用flunitrazepam個案必須謹慎監測是否發生複雜性睡眠行為，尤其是服用高藥物劑量者及酒精使用者。
並列摘要
Objectives: Complex sleep behaviors (CSBs) are often associated with the use of hypnotic drugs. This study aimed to investigate the prevalence and correlates of CSBs among patients taking flunitrazepam from psychiatric outpatient clinics. Methods: A total of 268 participants who were administered flunitrazepam from psychiatric outpatient clinics for at least 3 months were enrolled from June 2011 to May 2012. The following data were collected: occurrence of CSBs, demographic characteristics, the dosage of flunitrazepam and duration of its use, psychiatric diagnoses, physical illnesses, and alcohol use. Logistic regression analysis was used to examine the clinical correlates of CSBs. Results: Sixty-six (24.6%) participants reported experiencing CSBs. Logistic regression analysis showed that a high doagse (> 2 mg/d) of flunitrazepam (odds ratio [OR] = 1.941, 95% confidence interval [CI] = 1.090-3.455, p = .024) and the use of alcohol (OR = 1.948, 95% CI = 1.023-3.709, p = .042) were significantly associated with the occurrence of CSBs. Gender, age, the duration of flunitrazepam use, psychiatric diagnoses, and physical illnesses were not significantly associated with the occurrence of CSBs. Conclusions: CSBs among flunitrazepam users should be monitored routinely, especially among those with a high dosage of flunitrazepam who drink alcohol.