- 學位論文
藉由氯化碘進行葡萄糖胺及半乳糖胺的過氧乙醯化反應
Per-O-Acetylation of N-Acetylglucosamine and N-Acetylgalactosamine by Iodine Monochloride
摘要
摘要 乙醯化 (acetylation)反應為現今常用的有機反應，因此開發一個低成本，低毒性，且操作簡單的乙醯化方法是必需的。 論文使用乙酸酐當作乙醯化試劑，氯化碘 (ICl)作為催化劑對葡萄糖 (D-glucose)、N-乙醯葡糖胺 (N-acetyl-D-glucosamine)和N-乙醯半乳糖胺 (N-acetyl-D-galactosamine)進行乙醯化反應，其優點是催化劑使用前不須事先處理，不須額外使用溶劑，及反應時間短，其缺點是所得產物的產率低。由實驗結果得知，葡萄糖使用0.8當量氯化碘當催化劑，反應時間為14分鐘，而N-乙醯葡糖胺使用0.8當量氯化碘時，反應時間為3小時，N-乙醯半乳糖胺使用0.8當量氯化碘時，反應時間為1小時。
並列摘要
Abstact Acetylation is one of the most common organic reactions so that to develop a low cost, low toxicity and easy acetylation approach is necessary. In this study, the iodine monochloride was utilized as the catalyst for the acetylation of the N-acetylglucosamine, and N-acetylgalactosamine with acetic anhydride. The advantages of this methodology are that there would be no pretreatment on the catalyst, no solvent required, and reduce the reaction time. However, the disadvantage is the low yield for this acetylation. The resule showed that the reaction time for the D-glucose, N-acetyl-D-glucosamine, and N-acetyl-D-galactosamine is 14 min, 3h, and 1h, respectively, as the 0.8 eq of ICl was used.