摘要
睡眠是最好的休息方法，如果在白天常覺得疲倦或想睡覺，除了睡眠不足之外，也可能是有睡眠呼吸中止症。若想要確認便需要到醫院的睡眠醫學中心進行複雜費時的睡眠多項生理訊號檢查。為了因應使用居家睡眠檢查的方式，在家檢測睡眠呼吸中止症，美國睡眠呼吸學會規定居家睡眠監測儀器至少需要測量到呼吸氣流、呼吸努力與血氧飽和濃度三種訊號。 此研究針對阻塞型睡眠呼吸中止症檢測開發了微小型居家睡眠生理監測器，將呼吸氣流和血氧飽和濃度感測器結合在一起放置於鼻前，測量鼻中膈的血氧飽和濃度和口鼻呼吸氣流，利用藍牙無線傳輸將訊號傳至電腦進行分析。藉由控制呼吸深度、速率與閉氣的方式，以及利用多項睡眠生理訊號記錄器的同步量測結果來驗證呼吸中止檢測的準確性，並校正所量測到的血氧飽和濃度值。 實驗結果顯示在鼻中膈測量的血氧飽和濃度可以更迅速反應呼吸停止時的濃度變化，濃度校正範圍在88%至97%之間的相關性為0.96。長時間睡眠的測量結果也和睡眠多項生理訊號記錄器的結果相符。 未來若結合胸腹帶測量到呼吸努力將可分辨出中樞型與阻塞型呼吸中止症，提供更舒適且方便的居家睡眠檢查方式。
並列摘要
Sleep is the best form of rest. If one always feels drowsy or sleepy during the daytime, he might be not getting enough sleep at night, or he might have sleep apnea. In order to confirm the presence of sleep apnea, one has to undergo a complex and time-consuming sleep study, or polysomnography, in the sleep medicinal center of a hospital. According to the Clinical Practice Guidance of the American Academy of Sleep Medicine, an effective home sleep apnea testing device should record at least three basic signals: airflow, respiratory effort and blood oxygenation. In this study, a mini-device was developed for detecting obstructive sleep apnea at home. The airflow and blood oxygenation sensors are combined together for wearing in front of the nostril. The measurement of blood oxygenation was taken at the nasal septum, and the airflow through the mouth and nostrils were detected and transmitted to computer for analysis. The accuracy of apnea detection was verified by controlling the breathing rate and depth. A polysomnography and this device measured a breath-held experiment simultaneously to calibrate the measurement of blood oxygenation. The results showed that the blood oxygenation measured at the nasal septum could reflect the change in oxygen saturation faster than that was measured at finger. A correlation coefficient of 0.96 was achieved while calibrating the oxygen saturation in range between 88% and 97%. The long-term measurement results during sleep were also consistent with the results of polysomnography. To distinguish the central sleep apnea from the obstructive sleep apnea, chest and abdomen belt sensors have to be added to detect respiratory effort. This will provide a more comfortable and convenient way of sleep apnea home test.