- 學位論文
超音波探頭電漿滅菌設備設計與開發
DESIGN AND DEVELOPMENT OF PLASMA STERILIZATION EQUIPMENT WITH ULTRASONIC PROBE
摘要
目前超音波檢測是醫院主要使用的檢測方法之一，每天都有許多患者會使用到同一支超音波探頭，然而一直沒有完善的清潔方式，目前現有的消毒方式對於超音波探頭可能會有損壞風險，為了延長昂貴的超音波探頭使用壽命，需要減少使用消毒液的頻率，導致醫院存在交叉感染的風險。近年來，許多學者開始研究大氣電漿，並在各個領域廣泛應用。研究表明，電漿能夠在短時間內進行低溫滅菌，並且與傳統的消毒方法相比對人體較無害。基於這些背景，我們設計一套超音波探頭電漿滅菌設備，旨在取代傳統的滅菌方法，且不對超音波探頭造成危害，以期為醫院提供更安全、高效的超音波探頭滅菌方法。本研究使用介電層阻擋放電形式之電漿，製作出一組電漿反應器，並設計可針對超音波探頭使用的電漿滅菌設備，對本設備進行激發電漿時電漿電性檢測、激發電漿時電漿溫度檢測、利用光學放射光譜儀對電將激發時產生的電漿激發物種進行檢測以及激發電漿不同時間對細菌滅活效果之檢測，最後為了驗證電漿不會破壞探頭，進行超音波影像檢測與生物相容性測試。透過檢測結果可得知，本設備能在大氣壓力下激發空氣產生電漿物種中能夠滅菌的活性氧物種，電性結果之工作電壓為2千伏，工作電流為144毫安培，工作頻率為26.7千赫茲，消耗功率為6.27瓦。溫度在激發電漿8分鐘時達到48攝氏度。在6分鐘內能對大腸桿菌、金黃色葡萄球菌、多重抗藥性鮑氏不動桿菌、耐甲氧西林金黃色葡萄球菌100%滅菌。在超音波影像檢測與生物相容性檢測中可得知本設備不會影響超音波探頭。期望未來能夠開發自動化，並且能針對電漿對多重抗藥性鮑氏不動桿菌的研究往更多方面發展。
並列摘要
At present, ultrasonic testing is one of the main detection methods used in hospitals. Many patients use the same ultrasonic probe every day. However, there has been no perfect cleaning method. The existing disinfection methods may damage the ultrasonic probe. In order to prolong the service life of expensive ultrasonic probes, it is necessary to reduce the frequency of using disinfectant, which leads to the risk of cross-infection in hospitals. In recent years, many scholars have begun to study atmospheric plasma, which has been widely used in various fields. Studies have shown that plasma can sterilize at low temperature in a short period of time and is less harmful to the human body than traditional disinfection methods. Based on these backgrounds, we designed a set of ultrasonic probe plasma sterilization equipment, which aims to replace the traditional sterilization method without causing harm to the ultrasonic probe, in order to provide hospitals with a safer and more efficient ultrasonic probe sterilization method. In this research, a group of plasma reactors was fabricated by using the dielectric layer to block the discharge form of plasma, and a plasma sterilizing equipment that can be used for ultrasonic probes was designed. Plasma temperature detection during plasma generation, use of optical emission spectrometer to detect plasma excitation species generated when electricity will be excited, and detection of bacterial inactivation effect of plasma excitation at different times. Finally, in order to verify that the plasma will not damage the probe, carry out Ultrasonic imaging inspection and biocompatibility testing. Through the test results, it can be known that this equipment can excite air under atmospheric pressure to generate active oxygen species that can sterilize plasma species. The operating voltage of the electrical results is 2 kV, the operating current is 144 mA, and the operating frequency is 26.7 kilohertz and consumes 6.27 watts. The temperature reached 48°C when the plasma was excited for 8 minutes. Within 6 minutes, it can sterilize 100% of Escherichia coli, Staphylococcus aureus, multidrug-resistant Acinetobacter baumannii, and methicillin-resistant Staphylococcus aureus. In the ultrasonic image detection, it can be known that this device will not affect the ultrasonic probe. It is expected that automation can be developed in the future, and the research on plasma-resistant multidrug-resistant Acinetobacter baumannii can be developed in more aspects.