一、合成α 和 δ 咔吧啉的相位選擇性切換
二、以3-溴苯丙醛與2-胺基吲哚衍生物的去酯基合環反應而進行α咔吧啉的合成

利用吲哚查爾酮肟酯衍生物作為起始物並透過非金屬試劑的方式來合成出α 和 δ 咔吧啉。反應過程為溫和且利用了相位切換方法，而DDQ則作為切換試劑來選擇性合成出α 和 δ 咔吧啉。透過較穩定的3-溴苯丙醛與2-胺基吲哚衍生物來合成出-carbolin的方法學，具有高取代基容忍度、非金屬試劑、高效率、溫和的反應等等的重要優點。

關鍵字

咔吧啉；相位選擇性；吲哚；碘；非金屬

並列摘要

A metal-free protocol for accessing both α and δ-carboline derivatives, starting from a common indolylchalcone oxime ester precursor is reported. The reaction involves mild conditions and uses a regiodivergent approach. DDQ is used as a switching agent in selectively generating a and d-carboline derivatives in good to moderate yields. The present methodology described a versatile pathway to furnish -carboline from relatively stable 2-amino indole derivatives and 3-bromopropenal. High substrate tolerance, nonmetallic, more efficient and mild condition reaction are important aspects.

並列關鍵字

carboline ； regioselective ； indole ； iodine ； metal-free

參考文獻

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