In this paper, we combines MSP430 (G2553), Bluetooth module (BC417) and smart phone APP program design to implement a wireless portable system, which can be easily used to measure and record skin resistances on acupoints. By using a pressure control prober, the system can achieved a repeatability error of 1.5%. Before measurement, we connect the phone with Bluetooth. To use the APP program to select acupuncture points, then hold the reference electrode, the measurement probe contact with the skin acupuncture points. When the measurement is completed, MSP430 calculates the average and trend of the measured data, and then these results are sent and shown on the smart phone by the APP program.