Typical solder bonding process for flip chip assembly is performed above 200°C. The bond usually comes with thermal stress, misalignment, structural damage resulting in the reliability problem of packaging assembly. Besides, the pitch size of electrical input/output (I/O) is usually limited by the size of solder ball that further restricts the flip chip bonding technique for high density interconnecting application. Therefore, it is critical to develop the chip assembly technique with low processing temperature and small bump size. In this paper, piranha cleaning process combined with a conventional under bump metallization (UBM) process have been developed for realizing low temperature Au-Au thermally compressive bond (<200牵C) and it has shown the potential for the applications of fine-pitch interconnect and System-on-a-Packaging (SOP). Experimental results show that the gold content in the bonding surface can be increase 33.7% after a 240 seconds piranha cleaning to realize a Au-Au thermally compressive bond with a contact resistance of 45mΩat the conditions of 160℃ and 100MPa applied pressure.