餵食薑黃及木鱉果對倉鼠生理之影響

為了解薑黃素及番茄紅素對於倉鼠器官上的影響進而擬定實驗計畫。在此實驗中，以薑黃(薑黃素)及木鱉果(番茄紅素)之粉末連續餵食倉鼠一個月。本次實驗挑選體重100公克以上之倉鼠，並以每公斤倉鼠體重配上1公克之薑黃粉及木鱉果粉進行灌藥餵食，且每週執行個別秤重並記錄體重。後續將心臟、肝臟、肺臟、腎臟、大腸及小腸進行石蠟包埋組織切片且透過顯微鏡H&E染色鏡檢比較。實驗結果顯示，餵食倉鼠薑黃粉與木鱉果粉之肝臟與腸道(大腸及小腸)有明顯吸收差異，其餘心臟、肺臟及腎臟之組織切片與控制組相較後無明顯差異，故可判斷薑黃素及番茄紅素可經由腸道至肝臟達到保肝之功效。其中以薑黃粉餵食倉鼠與控制組之體重作為比較，發現餵食薑黃粉之倉鼠的體重起伏較小；而以木鱉果粉餵食倉鼠與控制組之體重起伏無明顯差異，故可推斷薑黃素有控制體重起伏之功效。

關鍵字

薑黃；薑黃素；木鱉果；番茄紅素；倉鼠

並列摘要

In order to understand the effects of curcumin and lycopene on hamster organs, an experimental plan was developed. In this experiment, hamsters were fed continuously for one month with powders of Curcuma longa (curcumin) and Momordica cochinchinensis (lycopene). In this experiment, hamsters weighing more than 100 grams were selected, and 1 gram of Curcuma longa powder and Momordica cochinchinensis powder were added to the weight of each kilogram of hamsters for feeding, and individual weights were performed weekly and weight was recorded. Subsequently, the heart, liver, lung, kidney, large intestine and small intestine were sliced and embedded in the sarcophagus and compared by microscopic H&E staining. The experimental results showed that there was significant difference in the absorption of the liver and intestines (large intestine and small intestine) between the hamster Curcuma longa powder and the Momordica cochinchinensis powder. The other tissue sections of the heart, lung and kidney were not significantly different from the control group. Therefore, it can be judged that curcumin and lycopene can achieve liver protection through the intestine to the liver. Comparing the body weight of hamsters fed with Curcuma longa powder and the control group, it was found that the weight of hamsters fed Curcuma longa powder was less fluctuating; while the weight of hamsters fed Momordica cochinchinensis powder and control group had no significant difference, it can be concluded that curcumin has control The effect of weight fluctuations.