- 學位論文
Trazodone在貓後肢運動步態分析的影響
The Effects of Trazodone on Cats' Hindlimbs Kinematic Gait Analysis
摘要
運動步態分析可用於輔助診斷跛行、評估治療成效和觀察病程進展，而貓隻在就診時的緊迫可能會影響檢查檢果，雖然就診前可藉由口服抗焦慮藥減輕貓隻的緊迫，但仍不清楚抗焦慮藥是否會對步態分析結果造成影響，因此本研究目的在於評估緊迫程度與抗焦慮藥對貓步態分析造成的影響。本研究募集12隻臨床上健康的貓隻，於步態檢查開始前1.5小時，分別經口投與trazodone 3 mg/kg（鎮靜組）或維生素B12（對照組），採隨機、交叉、雙盲設計，利用FAS及CSS量表評估貓隻的緊迫程度，此外也觀察貓隻對於trazodone的鎮靜反應。貓隻步態分析方式是讓貓隻走過2.2公尺長的透明隧道時，同時進行雙側後肢的拍攝及二維運動步態分析。結果顯示有1隻(8.3%)緊迫程度高的貓無法完成試驗；2隻(16.7%)貓投予trazodone後因嗜睡趴坐在走道無法完成試驗；最後有9隻(75%)貓納入運動步態分析試驗，且給予trazodone後出現不等程度的鎮靜效果。結果顯示對照組的左右腳髖關節活動範圍有顯著差異(p=0.0195)；貓隻在對照組及鎮靜組的緊迫程度及運動步態分析的結果皆無顯著差異；緊迫程度和雙側髖關節活動角度、膝關節最小彎曲角度及步距呈高度相關性。結論是就診前口服trazodone 3 mg/kg雖然對於緩解貓隻緊迫程度不明顯，但給予後可能產生的嗜睡效果會減少步態分析的成功率，因此不建議在步態分析前常規使用。緊迫程度也會影響貓步態分析的部分結果，所以在評估貓隻步態時，應將緊迫程度納入考量。
並列摘要
Kinematic gait analysis can assist in diagnosing lameness and evaluating the efficacy of treatment or the disease progression. However, the cat’s stress during analysis may influence the results. Previous studies highlight trazodone’s stress-reducing benefits in cats, but its impact on gait analysis remains unclear. Therefore, this study aimed to investigate the effects of trazodone and stress on feline gait analysis. This is a randomized, double-blind, and crossover study. Clinically healthy cats received either trazodone (3 mg/kg, sedated group) or a placebo (Vitamin B12, control group) orally 90 minutes before each gait analysis session. Stress levels were assessed using fear, anxiety, and stress (FAS) scale and cat stress score (CSS) scale. Twelve cats were enrolled in the study. Gait analysis of hindlimbs was conducted while cats walked through a 2.2-meter transparent tunnel. 1 cat with a high stress level failed to walk through the tunnel in both groups, while 2 cats in the sedated group refused to walk because of sleepiness. Eventually, 9 cats (75%) were recruited for kinematic gait analysis and showed signs of mild sedation when trazodone was given. A significant difference (p=0.0195) in bilateral hip joints range of motion was observed in control group. There were no significant differences observed in kinematic gait variables and stress scores between the sedated and control group. Correlations were observed between stress levels and angles of the hip and knee joints, as well as stride length during walking. It concluded that oral administration 3 mg/kg trazodone to cats before gait analysis did not reduce stress levels, and the sedative effect may have decreased their inclination to walk through the tunnel. Thus, routine use of trazodone before gait analysis is not recommended. Stress levels indeed influence the results of gait analysis. Therefore, the stress levels should be taken into consideration when evaluating a cat’s gait.