- 學位論文
台灣產粗榧屬台灣粗榧木質部之化學成份研究
Studies on the Chemical Components of the Heartwood of Cephalotaxus wilsoniana Hayata
若您是本文的作者，可授權文章由華藝線上圖書館中協助推廣。
摘要
台灣粗榧（Cephalotaxus wilsoniana Hayata），又稱為威氏粗榧或台灣三尖杉，為粗榧科(Cephalotaxaceae)，粗榧屬(Cephalotaxus)的植物，是台灣特有種的裸子植物。 台灣粗榧（Cephalotaxus wilsoniana Hayata）木質部，經室溫蔭乾、粉碎後以甲醇浸泡三次，每次七天，過濾後浸泡液濃縮乾得一甲醇粗萃物，然後利用管柱色層分析、薄層層析、再結晶等方法分離純化之，並利用光譜分析鑑定其化學結構，共得八個化合物。 分離所得固醇類化合物一個：β-Sitosterol (42)。芳香環類化合物六個： 4-hydroxy-3-methoxy benzoic acid (43)、4-hydroxy-3,5-dimethoxybenzaldehyde (44)、(E)-3-(4-hydroxy-3-methoxy phenyl) cinnamic acid (45)、4-hydroxycinnamic acid (46)、4-hydroxybenzaldehyde (47)、Syringic acid (48)。黃烷醇類化合物一個：(-)-Epicatechin (49)。其中，化合物(-)-Epicatechin (49)為台灣粗榧（Cephalotaxus wilsoniana Hayata.）中首次發現之天然化合物。
並列摘要
Cephalotaxus wilsoniana Hayata was Formosan original gymnosperm. The dried stems of Cephalotaxus wilsoniana Hayata were ground and soaked in methanol at ambient temperature. The solution was drained after a 3 day soak period, the residue stems were re-soaked in methanol for 3 days, and the solution re-drained at three times during a 9 day period. The filtered methanolic extracts were combined and concentrated under reduced pressure to a viscous residue. The residue was further isolated and purified by column chromatography, thin layer chromatography and re-crystallization. Ten constituents were found and their structures were established on the basis of spectral analysis and comparison with the literature data. These compounds included β-sitosterol (42), 4-hydroxy-3-methoxy benzoic acid (43), 4-hydroxy-3,5-dimethoxybenzaldehyde (44), (E)-3-(4-hydroxy-3methoxy phenyl) cinnamic acid (45), 4-hydroxycinnamic acid (46), 4-hydroxybenzaldehydre (47), Syringic acid (48), (-)-Epicatechin (49). Among the isolated compounds, (-)-Epicatechin (49) was new found in Cephalotaxus wilsoniana Hayata.
參考文獻
2. Newman, D. J., Cragg, G. M., and Snader, K. M., “Natural Products as Sources of New Drugs over the Period 1981-2002,” J. Nat. Prod., Vol. 66, No. 7, pp. 1022-1037 (2003).
3. Cragg, G. M., Newman, D. J., and Snader, K. M., “Natural Products in Drug Discovery and Development,” J. Nat. Prod., Vol. 60, No. 1, pp. 52-60 (1997).
4. Newman, D. J., Cragg, G. M., Holbeck, S., and Sausville, E. A., “Natural Products and Derivatives as Leads to Cell Cycle Pathway Targets in Cancer Chemotherapy,” Current Cancer Drug Targets, Vol. 2, No. 4, pp. 279-308 (2002).
5. Wiley, R. A., and Rich, D. H., “Peptidomimetics Derived from Natural Products,” Med. Res. Rev., Vol. 13, No. 3, pp. 327-384 (1993).
10. Weinreb, S. M., Auerbach, J., “Total Synthesis of the Cephalotaxus Alkaloids. Cephalotaxine, Cephalotaxinone, and Demethylcephalotaxinone,” J.Am. Chem. Soc., Vol. 97, No. 9, pp. 2503-2506 (1975).