- 學位論文
龍腦冰片β-環糊精包合物之研究
Study on Borneol β-cyclodextrin inclusion complex
摘要
冰片為傳統常用中藥，具消炎、鎭痛、防腐的作用，研究指出右旋效果優於左旋與消旋，但因純化後呈結晶狀，且冰片有揮發性、刺激的氣味，所以不利於化妝品的使用。 本研究採用β-環糊精將高純度龍腦冰片進行包合，利用飽合水溶液法製備和冷凍乾燥法乾燥，冰片β-環糊精包合物呈粉末狀，回收率為84.9±2.9%。利用掃描式電子顯微鏡與傅立葉轉換紅外線光譜儀(FTIR)來鑑定是否包合，電子顯微鏡發現冰片結構改變，FTIR光譜吸收峰降低、位移或消失，代表冰片與β-環糊精產生包合。用GC來定量包合率為91.1±3.2%。檢測冰片β-環糊精包合物和混合物熱穩定，冰片被環糊精包合後增加熱的穩定性，減少冰片的揮發效率，能掩蓋冰片刺激氣味。進一步能將包合物添加至市售化妝品中應用。
並列摘要
Borneol is the traditional Chinese medicine posed anti-inflammation, analgesic and antibacterial activities. The d-borneol after purification is forming crystallization. It is also have stimulation and sublimation property that can’t use in the cosmetic product widely. Therefore, in this study, we used the method of saturated water solution and freeze drying to remove the part of not inclusion borneol and then drying. The recovery rate of borneol β-cyclodextrin powder is 84.9 ± 2.9 ％. Evaluation the index of the β-cyclodextrin inclusion rate in complex by the scanning electron microscope (SEM) and fourier transform infrared (FTIR) spectrometer. The inclusion rate is assayed by gas chromatography (91.1 ± 3.2 ％). Furthermore, we also inspected the temperature influence of β-cyclodextrin inclusion and mixtures. The result showed β-cyclodextrin inclusion is more stable. Otherwise, the inclusion can decrease the odor, the rate of sublimation and hope application in cosmetics in future.