摘要
上皮組織是由口腔外胚層衍生而出，可形成牙齒牙釉器官分泌牙釉基質。在早期的牙齒發育中，生長因子調節訊息已暗含在上皮與間葉組織相互作用。此外，像msh homeobox的基因- Msx1與Msx2等推想複製因子，也會反應表現在發育中的牙齒。在間葉匯聚的過程中，間葉組織變成能引導牙齒的形成。一連串造釉細胞的分化包括前造釉細胞tight junction構造特徵、分泌造釉細胞之分泌功能、成熟造釉細胞之質子幫浦等，是與高度結晶的牙釉形成超結構體有密切的關係。牙釉質形成素基因則僅表現在牙釉質形成中的分泌期。(Taiwan J Pediatr Dent 3(1): 1-12, 2003)
並列摘要
The epithelium, derived from the oral ectoderm, forms the enamel organ of the tooth which secretes the enamel matrix. Growth factor-mediated signaling has been implicated in the regulation of epithelial-mesenchymal interactions during early tooth development. Moreover, the msh-like homeobox genes – Msx1 and Msx2, as putative transcription factors, are also in response to express in the developing tooth. During the condensation process, the mesenchyme becomes capable of inducing tooth formation. A series of cytological differentiation of ameloblasts, including the structural features of tight junction in premeloblasts, the secretory function of secretory ameloblasts, and proton-pump activity in maturation ameloblasts is considered to be closely associated with highly crystallized enamel-formation ultrastructure. The amelogenin gene is expressed only during the secretion stage of amelogenesis. (Taiwan J Pediatr Dent 3(1): 1-12, 2003)