The purpose for this project is from the viewing point of the clinical physician and the tumor specialist to investigate the motive and effect of the urine therapy by interviewing the urine therapy family. Then, we can sustain the reliability of the popular folklore urine therapy. The targets of this project are 300 members of the Taiwan Urine Therapy U-nion. Results from the interviewing show apparent symptom progress of peri-odontosis, hypertension, diabetes mellitus and degenerative arthritis. It is also improves the liver function of the hepatitis's patient. The selected targets also re-quire indirect symptom progress such as the improvement of the hair and skin, mental condition and physical foree, function of gastrointestinal tract and condi-tlon of constipation. Besides that. the sensitize predisposition, influenza and awareness of cold for targets are also with better improve.