- 期刊
與後天再生不良性貧血有關聯的全口齒槽骨壞死
Pan-oral Alveolar Bone Necrosis Associated with Acute Acquired Aplastic Anemia
摘要
再生不良性貧血是一種骨髓內造血功能受到抑制的疾病，患者可能因為貧血造成身體倦怠虛弱，因血小板減少造成黏膜出血，因白血球減少造成口咽或上呼吸道感染。本文提出一位七十四歲的男性患者，他於2001年2月因長途旅行後全身倦怠和發燒住進振興醫院，在此被診斷為急性後天再生不良性貧血，住院期間一系列血球數均為減少現象，在2001年2月28日紅血球數目為3.05×10^6/mm^3，白血球數目為320/mm^3，血小板數目為17000/mm^3，骨髓抽吸病理組織報告均顯示為再生不良性貧血。住院期間患者口內出現嚴重牙齦萎縮，牙齦潰瘍合併齒槽骨暴露，以及全口牙齒米蘭氏(Miller)第三度動搖，這些症狀在臨床上同時出現很不常見。由於患者症狀日漸嚴重於2002年6月住進本院就診，在給予抗生素之後，接受全口拔牙以及腐骨切除術，術後傷口癒合良好。
並列摘要
Acute aplastic anemia is defined as peripheral pancytopenia associated with hypocellular bone marrow in which hemotopoietic function is suppressed. They may suffer from general malaise and weakness, mucosal hemorrhage or upper respiratory infection. This case report was a 74 years old male patient. He felt general malaise and had fever after long distance travel then was admitted to Cheng-Shin Hospital. He also had DM, TB and hepatitis B, C in the past medical history. In February 2001, he was diagnosed and treated as acute acquired aplastic anemia. The sessions of laboratory data showed pancytopenia. For example, on Feb 28, 2001, the WBC count was 320/mm^3, the thrombocyte count was 17000/mm^3, the RBC count was 3.05×106/mm^3. In the meanwhile, he had severe tooth mobility, severe gingival recession with the exposure of alveolar bone in the remaining teeth. The oral condition got worse gradually. In June 2002, he was admitted to our hospital to receive sequestrectomy and teeth extraction under the coverage of antibiotics. The wound healing was even postoperatively.