- 期刊
低度唾液腺管道癌－病例報告
Low-Grade Salivary Duct Carcinoma: A Case Report
摘要
唾液腺管道癌(salivary duct carcinoma, SDC)是一種因爲管道組織增殖形成類似膨脹的唾液腺管道的高度惡性腫瘤，其腫瘤細胞以管道細胞(ductal cell)爲主，腫瘤具侵犯性且預後很差。低度唾液腺管道癌(low-grade salivary duct carcinoma, LGSDC)不同於唾液腺管道癌，是一種因爲管道內細胞增殖所形成的惡性腫瘤，其腫瘤細胞由多種細胞組成且惡性度較低，腫瘤較不具侵犯性且預後良好。本報告報導一位33歲男性主訴左臉頰腫塊，臨床發現其左側史坦生氏管孔區域(Stensen's duct)有一腫塊，病理切片呈現管道內唾液腺管道樣上皮增生，免疫化學染色呈現S100、AE1/AE3、Vimentin、EMA顯性，顯示此病灶爲一低度唾液腺管道癌。本病例施行腫瘤廣泛性切除手術並以頰脂墊(buccal fat pad)修補，術後癒合良好，目前並無復發或轉移現象。
關鍵字
唾液腺管道癌並列摘要
Salivary duct carcinoma (SDC) is a rare, high-grade malignant epithelial neoplasm which composed predominantly or exclusively of ductal cells with the formation of structures resembling distended salivary duct. It follows an aggressive clinical course and carries a poor prognosis. However, low-grade salivary duct carcinoma (LGSDC) represents a low-grade neoplasm as a variant of salivary duct carcinoma. It is characterized by a heterogeneous intraductal proliferation process, a non-aggressive clinical course, and a good prognosis. We describe a case of low-grade salivary duct carcinoma arising from the Stensen's duct. The patient was a 33-year-old male who presented a firm mass in the buccal mucosa around the left Stensen's duct orifice. Microscopic examination showed intraductal proliferation of salivary duct-type epithelium with papillary and solid pattern. In immunohistochemical study, the tumor cells were positive for S100, AE1/AE3, Vimentin, and EMA. The overall feature was most compatible with a low-grade salivary duct carcinoma. The patient remains well following wide excision and buccal fat pad reconstruction.