Objective: To study the curative effect of the formula -Zhuangyang Huichun promote blood circulation to regulate menstruation-on Pastille, which can invigorate kidney to reserve essence and patients with sterility of kidney-yang asthenia. Method: Clinical observation about 30 outpatients with sterility of kidney-yang asthenia was conducted. Result: This formula could promote the follicular development, ovulation and synchronous reaction of periovulatory endometrium. The pregnant rate reached to 73%. The symptoms of kidney-yang asthenia were improved markedly. Conclusion: The Zhuangyang Huichun Pastille, which was used to sterility of kidney-yang asthenia in this research, might be recommended in clinical application because of its multi-factor advantages and absence of side effect.