牡丹皮、天門冬精華液在減輕女性臉部皮膚暗沉之研究

前言：傳統中醫認為當人體長期處於體液缺乏（陰虛），血瘀和血熱會造成發炎後色素沉著。臨床中醫通常使用滋陰中藥，如天門冬來滋養人體體液及皮膚，並利用活血化瘀中藥如牡丹皮來促進血液循環來治療發炎後色素沉著。先前研究已證實天門冬和牡丹皮萃取物有效地抑制黑色素細胞的酪氨酸酶活性，但尚未有相關實證醫學研究來探討其皮膚美白功效。本研究目的在探討含有天門冬及牡丹皮萃取物的精華液對女性發炎後色素沉著之改善效果。方法：本研究是隨機單盲臨床試驗，共有60位年齡為25至60歲健康女性受試者，其Fitzpatrick皮膚類型為III及IV型，將其隨機分為3組，0.5%牡丹皮、天門冬精華液，2%牡丹皮、天門冬精華液及未含牡丹皮、天門冬精華液之安慰劑，每組各20人。受試者每日2次臉部清洗後塗抹樣品於皮膚暗沉部位。之後在試驗前（第0週）及試驗後（第8週）經數位膚質檢測儀（VISIA）評估臉部黑色素程度。結果：在使用後的第8週，0.5%及2%牡丹皮、天門冬精華液確實改善受試者全臉的皮膚表淺斑點（p＜0.05）。結論：含有牡丹皮及天門冬萃取物精華液對皮膚色素沉著的受試者具有良好美白效用，未來可做為皮膚嫩白的保養品原料應用在化粧品或醫藥品產業上。

關鍵字

皮膚色素沉著；牡丹皮；天門冬；數位膚質檢測儀

並列摘要

Traditional Chinese Medicine (TCM), one form of CAM, has indicated that long term body fluid deficiency(津液缺乏), blood stasis(血瘀)and blood heat(血熱)can cause SHD. Clinical TCM usually uses the enrich yin(滋陰) herb, such as Asparagus cochinchinensis (Ac), to nourish the human body fluid and moisturize the skin for improving skin metabolism, resulting in skin whitening. In addition, TCM also uses the angiogenesis promoting herb, such as Paeonia suffruticosa (Ps), to cure SHD through promoting blood circulation to dispel blood stasis(活血化瘀). Previous studies have revealed that the extract of Ps and Ac can effectively inhibit tyrosinase activity in melanocytes, but the evidence base for its skin whitening effect has not been investigated yet. In the present study, The lotion containing the extract of Ps and Ac was used to attenuate skin pigmentation in female subjects through a pilot study. This is a randomized, placebo-controlled, single-blind clinical trial. Sixty female subjects aged between 25 and 60 were enrolled, and their Fitzpatrick skin types were type III to IV Asian skin with hyperpigmentation conditions. There are three randomized groups in this pilot study, including 0.5% and 2% lotion and placebo, with 20 subjects in each group. All subjects in each group were administered various test samples in facial pigmentation areas twice a day after cleaning. Before (0 week) and after (8 week) treatment, all subjects were non-invasively evaluated by VISIA® photography. The results indicated that there was a significant decrease in superficial spots on the entire face after using 0.5% and 2% lotion (p＜0.05). In summary, The lotion can effectively improve the skin pigmentation of subjects and displays skin whitening effect, and we suggest that the lotion may be used as a skin whitening product in the cosmetic or pharmaceutical industry in the future.

並列關鍵字

Skin pigmentation ； Paeonia suffruticosa ； Asparagus cochinchinensis ； VISIA® photograp

參考文獻

Ismail Z, Affandi Yusoff MS, Hashim K. Ultra Moisturizing Skin Whitening Lotion Enriched with Tocotrienols, Journal of Dispersion Science and Technology. 2009; 30(1): 72-75.