- 期刊
中藥介入治療對新冠肺炎重症療效評估
Evaluation of the Curative Effect on Traditional Chinese Medicine in Severe Coronavirus Disease (COVID-19)
摘要
背景：新型冠狀病毒肆虐全球，該病毒不僅有高傳染力，感染後亦有較高的重症機率，因此西醫或中醫皆朝著能夠有效抑制病毒繁殖和減少重症的方向努力。受Severe acute respiratory syndrome coronavirus 2（SARS-CoV-2）感染的患者中，存在高炎症反應及免疫抑制的狀況，根據先前中醫以中藥治療SARS的經驗，發現中藥具有抗發炎、抗病毒及免疫調節的特性，因此適當的中藥介入對於治療新冠肺炎患者能有一定程度上的效果。方法：本研究描述了7名由台中慈濟醫院收治入院的COVID-19重症患者，均接受西醫常規治療，其中有5名同時接受中醫藥物治療。結果：中藥介入治療組與無中藥介入治療組相比，在症狀緩解速度（住院天數）及病毒量衰退速度（病毒篩檢陽性轉陰性或Cycle Threshold值<30的時間），相較於無中藥介入有更佳的表現。結論：在COVID-19重症住院患者中，中藥治療搭配西醫常規治療與單純西醫常規治療相比，有較能緩解症狀及增快病毒衰退速度的趨勢，差異並不是非常顯著，可能受限於研究族群過小，若未來能有更多更大型的相關研究，相信可以更看出中藥介入COVID-19重症患者的有效性。
並列摘要
Background: The new coronavirus is raging around the world. This virus is not only highly infectious, but also has a high mortality rate once humans are infected. Therefore, both Western and Chinese medicine are trying to find effective drugs, which can block the reproduction of the virus and prevent the COVID 19 patients progressing to severe illness. Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a high inflammatory response and immunosuppression in the clinical course. According to the previous experience of the treatment against SARS, it has been found that Traditional Chinese Medicine has anti-inflammatory, antiviral and immunomodulatory properties. Therefore, appropriate treatment with Traditional Chinese Medicine have great opportunity to help COVID 19 patients accelerate recovery. Method: We describe a series of seven patients who were tested positive and admitted to Taichung Tzu Chi Hospital. After admission, they were all classified as severe illness according to their clinical conditions. Two of them (control group) were only treated with standard Western medicine at Taichung Tzu Chi Hospital, and five of them treated with standard Western medicine combined with Chinese Herbal Medicine (CHM). Results: Among the 7 severely ill patients admitted to this hospital, the CHM group compared with the control group, not only the speed of symptom relief (days of hospitalization) but the speed of virus decline (virus screening time from positive to negative or Cycle Threshold value < 30) are better than the control group. If compared with other antiviral drug related papers, good curative effects can be obtained in the above two indicators. Only in terms of the speed of symptom relief, there is still room for improvement when discussing with China's TCM formula-Qingfei Paidu decoction against COVID 19. Conclusion: Chinese Herbal Medicine against COVID 19 can significantly shorten the duration of hospital stay and virus decline.