Tumoral calcinosis is an uncommon disease in peritoneal dialysis patients. However, if it occurs, it may cause joint pain and limited mobility, which affects the quality of life. Because peritoneal dialysis patients need long-term use of calcium-containing phosphorus binders and excessive intake of high-phosphorus foods in the diet, it is easy to cause calcium and phosphorus imbalance and hyperthyroidism in the long-term, which leads to the deposition of calcium and phosphorus in soft tissues, causing tumoral calcinosis. The improvement of this disease requires a low-phosphorus diet, a use of a calcium-free phosphorus binder, and a low-calcium dialysate. Parathyroidectomy, surgical removal of the lesion, or kidney transplantation may also be benefit to improve this disease.