- 期刊
Klotho與FGF23在慢性腎臟病的生物標記角色
The Biomarkers Role of Klotho and FGF23 in Chronic Renal Disease
摘要
細胞膜Klotho（mKlotho）主要在腎臟表現，作用為成纖維細胞生長因子23（fibroblast growth factor 23, FGF23）的共同受體，協助FGF23的訊息傳遞功能；FGF23需與FGF受體和mKlotho結合來活化其維持礦物質平衡功能。當mKlotho被分泌酵素切斷，形成soluble Klotho，循環於血中，其功能不只在協助FGF23訊息傳遞，同時也扮演著酵素與荷爾蒙功能。在高濃度下，FGF23亦可在沒有Klotho協助單獨執行其生物效能。在早期腎臟病變，Klotho逐步下降而FGF23卻逐漸上升，本文探討Klotho與FGF23做為腎臟病生物標記與心血管疾病預後的重要性，同時闡釋其治療的潛在角色。
並列摘要
Membrane-bound Klotho is highly expressed in the kidney and functions as a co-receptor of fibroblast growth factor receptors (FGFRs) to activate specific fibroblast growth factor 23 (FGF23) signal pathway. The main function of FGF23 is to maintain mineral homeostasis within the body. Klotho found in the circulation is known as soluble Klotho which is derived from the cleavage of the extracellular domain of transmembrane Klotho by secretases. Soluble Klotho does not only activate FGFRs to transduce the FGF23 signaling pathway, but also acts as an endocrine, paracrine, and autocrine substance to play a variety of biological functions. Both serum and urinary Klotho decline at an early stage of chronic kidney disease followed by a rise in serum FGF23. This article attempts to delineate Klotho/ FGF23 axis as an important diagnostic and/or prognostic biomarkers for chronic kidney disease and cardiovascular disease and possibly as a novel therapeutic target for chronic renal disease.