非類固醇消炎止痛藥相關的急性腎損傷

Nonsteroidal Antiinflammatory Drugs Related Acute Kidney Injury

蔡宗穎(Tsung-Yin Tsai) ； 蔡尚峰(Shang-Feng Tsai)

《腎臟與透析》 32卷1期 (2020/03) Pp. 11-16

https://doi.org/10.6340/KD.202003_32(1).0003

摘要

非類固醇消炎止痛藥（nonsteroidal antiinflammatory drugs, NSAIDs）可能會造成腎臟所有組織的傷害，其中最常見的就是急性腎損傷（acute kidney injury, AKI）。NSAID的使用在臨床上相當常見，因此，如何辨識出高危險群就相當重要。機轉上來說，造成腎絲球灌流下降的任何原因，就是NSAID相關AKI的危險因子。不同環氧化酶（cyclooxygenase-1 and cyclooxygenase-2 [COX-1 and COX-2]）選擇性的NSAID皆會造成AKI，但似乎存在著不一樣的AKI風險。

關鍵字

非類固醇消炎止痛藥 ； 急性腎損傷 ； 腎絲球灌流不足

並列摘要

Nonsteroidal antiinflammatory drugs (NSAIDs) could induce injuries to all tissues of kidney, including glomeruli, tubules, interstitial, and vessels. Acute kidney injury (AKI) is the most common type of NSAID associated renal injury. In clinical practice, the prescription of NSAID remains very common even with chronic kidney injury. Any conditions regarding hypoperfusion of glomeruli are risk factors of NSAID related AKI. The difference of cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) inhibition may differ for the renal function deterioration after taking NSAIDs.

並列關鍵字

nonsteroidal antiinflammatory drugs (NSAID) ； acute kidney injury ； cyclooxygenase-2 (COX-2) inhibitor