The management of patients with acute kidney injury is mainly supportive and dialysis is indicated in patients with severe acute kidney injury. The utilization of dialysis in AKI patients resolves uremic symptoms and prevents complications such as immediate death. In this article, we reviewed the latest clinical guidelines and clinical trials regarding indications, optimal timing, type of modality, dosing strategy, hemodynamic considerations, when to withdrawal dialysis and dialysis factors that may influence renal function recovery in AKI patients. At last, there are conflicting data concerning the effect on mortality of continuous renal replacement therapy versus intermittent hemodialysis.