Baclofen中毒的診斷與治療

Diagnosis and Therapy for Baclofen Overdose

陳璽之(Hsi-Chih Chen) ； 許育瑞(Yu-Juei Hsu)

《腎臟與透析》 32卷3期 (2020/09) Pp. 138-143

https://doi.org/10.6340/KD.202009_32(3).0007

摘要

Baclofen是常用來治療中樞神經疾病導致的肌肉痙攣的藥物，然而在急性過量尤其在腎功能不良病人使用此藥時可能會併發嚴重副作用，包括腦病變、癲癇、意識昏迷、厭食症、低體溫、心臟及呼吸抑制等。本文旨在探討對於使用baclofen的病人產生相關症狀時，如何能即時診斷及給與適當的治療。

關鍵字

baclofen ； baclofen相關中毒 ； 腎功能不全

並列摘要

Baclofen is commonly used to treat muscle spasms secondary to central nervous system diseases. However, in acute baclofen overdose, especially in patients with renal dysfunction, it may be accompanied by severe toxicity, including encephalopathy, epilepsy, coma, anorexia, hypothermia, cardiac, or respiratory depression. The purpose of this article is to discuss the timely diagnosis of acute baclofen intoxication when they develop relevant symptoms, as well as provide an appropriate approach to treat baclofen overdose.

並列關鍵字

baclofen ； baclofen overdose ； renal impairment