- 期刊
1-84 PTH更適用於慢性腎性骨病變之管理
To Assay the 1-84 PTH Is More Suitable for CKD-MBD Management
摘要
副甲狀腺素（parathyroid hormone, PTH）的檢測，是反映副甲狀腺功能最可靠的生物標誌，提升分析速度，優化檢測敏感性與特異性，協助臨床更精準地評估副甲狀腺功能，對於腎性骨病患者的臨床診斷、治療及預後具有相當重要性。有學者認為全段（intact）PTH數值會高估副甲狀腺功能，所以不建議用來指導慢性腎臟病—礦物質骨病變（chronic kidney disease-mineral and bone disorder, CKD-MBD）的診斷和治療。我們檢測隨機107份血液樣本比較全長PTH（1-84 PTH）與全段PTH的差異，發現1-84 PTH約為全段PTH的50～60%，因為1-84 PTH是有生理活性的，所以更適合應用於CKD-MBD的治療與管理。
並列摘要
Parathyroid hormone (PTH) detection is the most reliable biomarker reflecting parathyroid function. It can improve the analysis speed, optimize the sensitivity and specificity of detection, and help the clinical assessment of parathyroid function more accurately. It is very important for the clinical diagnosis, treatment, and prognosis of patients with renal osteopathy. Some scholars think that the value of intact PTH will overestimate the parathyroid function, so it is not recommended to guide the diagnosis and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). We tested 107 random blood samples to compare the difference between whole PTH (1-84 PTH) and intact PTH and found that 1-84 PTH is about 50-60% of intact PTH because 1-84 PTH has biological activity, so it is more suitable for the diagnosis and treatment of MBD in CKD patient.