腸道菌群與腸－腎軸的相互作用關係

Interaction Between Gut Microbiota and Gut-Kidney Axis

鄭美美(Mei-Mei Cheng) ； 周榮敏(Jung-Min Chou) ； 譚健民(Chien-Min Tam)

《腎臟與透析》 32卷3期 (2020/09) Pp. 160-163

https://doi.org/10.6340/KD.202009_32(3).0011

摘要

健康人腸道菌群是一個極為複雜的細菌共生體，其中有超過100萬億個細菌細胞，並涵蓋著1000個各種不同種屬的菌株。在近幾年來的臨床研究中，顯示腸道菌群改變與小腸細菌過度生長、慢性腎臟病、心血管疾病、肥胖症、非酒精性脂肪肝疾病、類風濕關節炎甚至憂鬱症都有著密切的因果關係。近十幾年來的研究報告，顯示腎臟功能逐漸持續損傷以及其後遺症，有可能導源於腸道菌群菌株間組合及其數量的改變，使得慢性腎臟病患者衍生全身炎症反應。

關鍵字

慢性腎臟病 ； 腸道菌群 ； 腸腎軸 ； 益生菌 ； 急性腎損傷

並列摘要

The gut microbiota of healthy human is an extremely complex bacterial symbiosis with more than 100 trillion bacterial cells and covering 1000 strains of various species. The clinical studies in recent years have shown that gut microbiota changes induce small intestinal bacterial overgrowth, chronic kidney disease, cardiovascular disease, obesity, non-alcoholic fatty liver disease, rheumatoid arthritis and even depression. Reports of research in the past 10 years have also shown that renal function and its sequelae may be caused by changes in composition and amount of gut microbiota, leading to systemic inflammatory responses in patients with chronic kidney disease.

並列關鍵字

chronic kidney disease ； gut microbiota ； gut-kidney axis ； probiotics ； acute kidney injury