- 期刊
局部節段型腎絲球硬化症的治療
Treatment of Focal Segmental Glomerulosclerosis
摘要
局部節段型腎絲球硬化症（focal segmental glomerulosclerosis, FSGS）是常見的成人原發性腎病症候群。治療大致上分為兩大部分，分別為腎病／腎炎症候群的支持性治療以及免疫抑制治療的使用。支持性藥物的部分以angiotensin converting enzyme inhibitor/angiotensin II receptor blocker的角色最為重要，因其能降低末期腎病變的發生。免疫抑制劑的部分，若病患符合原發性FSGS定義，則建議接受高劑量口服類固醇做為第一線免疫抑制治療。其他未符合原發性FSGS診斷的分類，則需要積極找尋所有可能的次發性原因。
並列摘要
Focal segmental glomerulosclerosis (FSGS) is a common cause of primary nephrotic syndrome in adults. The treatment of FSGS includes two parts, supportive treatment for nephrotic/nephritic syndrome and the use of immunosuppressive therapy. Angiotensin converting enzyme inhibitor/angiotensin II receptor blocker is the most important role in supportive treatment because it can decrease the risk of end stage kidney disease. If a patient is diagnosed with primary FSGS, high- dose oral glucocorticoids as the first-line immunosuppressive treatment is recommended. For other classifications of FSGS, aggressive evaluation for possible secondary etiologies is needed.