狼瘡性腎炎（Lupus Nephritis）之最新治療

Latest Advancements on the Treatment of Lupus Nephritis

李宗翰(Tsung-Han Lee) ； 林志慶(Chih-Ching Lin)

《腎臟與透析》 34卷4期 (2022/12) Pp. 178-182

https://doi.org/10.6340/KD.202212_34(4).0005

摘要

狼瘡性腎炎（lupus nephritis, LN）是紅斑性狼瘡常見的併發症之一，即使科學界對於LN的病生理學越來越了解，治療策略的演進仍無劃時代性的突破，疾病進展到腎臟衰竭的病人比例依舊相當高，而且，有LN的紅斑性狼瘡病患比起沒有這項併發症的病患，其死亡率及末期腎病變比率均大幅提高，尤其是那些對治療沒有反應的病患，因此，給予即時適切的治療至關重要。

關鍵字

狼瘡性腎炎 ； 紅斑性狼瘡 ； 腎炎症候群

並列摘要

Lupus nephritis (LN) is one of the common complications of systemic lupus erythematosus. Although there has been extensive research conducted evaluating the pathophysiology of LN, treatment strategies remain few and the proportion of patients with LN progressing to kidney failure remains high. Furthermore, mortality and progression to end-stage renal disease rates are even significantly higher in patients with LN compared to those without, especially for treatment non-responders. Therefore, prompt and proper treatment for these patients is critical.

並列關鍵字

lupus nephritis ； systemic lupus erythematosus ； nephritic syndrome