- 期刊
Pharmacokinetic Difference between Licorice and Honey-processed Licoricein Rabbits
甘草與炙甘草於免體之動力學差異
摘要
目的 甘草與炙甘草為中醫臨床常用的中藥。本研究目的係探討未經炮製之甘草與炙甘草之藥物動力學差異。 方法 六隻家兔以交叉設計分別餵食甘草水煎劑與炙甘草水煎劑。以HPLC方法定量血清及糞便懸浮液中甘草酸、甘草次酸之濃度。利用非室性模式計算動力學參數，並以pai1red Student's t test 比較兩者問之差異。 結果 家兔分別口服甘草水煎劑與炙甘草水煎劑後，兩種水煎劑問之甘草酸藥物動力學參數無顯著差異，但血清中甘草次酸的AUC，口服炙甘草水煎劑比甘草水煎劑增加了480％。以糞便懸浮液溫孵之體外實驗顯示，蜂蜜顯著促進甘草酸水解為甘草次酸。 結論 蜜炙顯著影響了甘草中甘草酸的體循環前代謝，導致甘草次酸的血中濃度增高，可能因而增加甘草之藥效與毒性。（中台灣醫誌2004 ; 9 : 73 • 9 )
並列摘要
Objectives. Licorice and honey-processed licorice are widely used in clinical Chinese medicine for a variety of conditions and ailments. In this study, we investigated the difference in pharmacokinetics between unprocessed licorice and honey-processed licorice. Methods. Six rabbits were given decoctions of unprocessed licorice and honey-processed licorice in a crossover design. The concentrations of glycyrrhizin and glycyrrhetic acid in serum as well as glycyrrhetic acid in feces suspension were determined by HPLC methods. The pharmacokinetic parameters were calculated by a noncompartment model and statistical comparison was made by paired Student's t test. Results. No significant difference in pharmacokinetics of glycyrrhizin was found between the two treatments; however, licorice processed with honey increased the AUC of glycyrrhetic acid by 48%. The hydrolysis of glycyrrhizin to glycyrrhetic acid in feces suspension was greatly enhanced by the addition of honey. Conclusions. Honey processing of licorice affected the presystemic metabolism of glycyrrhizin and resulted in the elevation of blood levels of glycyrrhetic acid, which indicates that honey might increase the efficacy and toxicity of licorice. ( Mid Taiwan J Med 2004;9:73-9 )