- 期刊
臺灣市售桑寄生對酒精性肝腎損傷療效及消除自由基之評估
The Scavenging Free Radical Effect and reno-hepatic Protection of "Sang Jisheng" on Alcoholic Damage in Rats
摘要
桑寄生是我國古代沿用至今的常用藥材之一，始載於《神農本草經》，列為上品，原名桑上寄生。臺灣市售寄生藥材，有槲寄生Viscum colortum (KOM) NAKAI（簡寫為VC）及臺灣產之大葉桑寄生Taxillus liquidambaricolus (HAYATA.) HOSOKAWA.（簡寫為TL）。藥典記載其具有袪風濕，補肝腎，強筋骨，安胎之功效。用於風濕痹痛，腰膝酸軟，胎動不安。一般認為具有行血，壯筋骨，降血壓之效。治血崩，妊婦血漏，產後疾患，腰痛，腫毒等及有保肝之活性。民間有用於肝炎的治療，且傳統認為其具有補肝腎之功效。因此推論對肝、腎應具有明確保護作用。本研究對市售大葉桑寄生(TL)及槲寄生(VC)之甲醇抽出物以Chemiluminece Analyzer證實其清除自由基之效力。 並以酒精(Et-OH)誘發大鼠肝腎損傷，以進行其保肝護腎之療效評估。結果由生化指標，大葉桑寄生及槲寄生皆具有保肝護腎的功能。另外，由病理組識切片觀察發現此兩種寄生能夠減少Et-OH誘發的發炎、充血、壞死等損傷。此種結果與血清之生化指標作用吻合。而消除自由基(H2O2)之其作用是寄生保肝護腎的機轉之一。
並列摘要
Jisheng is one of the most commonly used Chinese medicines since ancient China. It was first described in ”Shen-Nong Ben-Tsao Jing”, called ”Shang Jisheng” which was classified into the top Chinese medicine. In Taiwan trade market Taxillus liquidambaricolus (Hayata.) Hosokawa (TL) and Viscuin colortuni (Kom.) Nakai (VC) were used as the Jisheng in the prescription. ”Ben Jing” and ”Yao Dian” described the Jisheng can treat rheumatism, disease of liver or kidney, upset at gestation and hypertension. In folk therapy, Jisheng is usually to treat hepatitis. ”Compendium of Materia Medica” also described that the Jisheng can nourish the liver and kidney. Therefore, it can reasonably be proposed that the Jisheng should have the effects to protect the liver and kidney. This research takes things out to verify its effect of scavenging the free radical with Chemiluminese Analyzer to TL and YC. To further evaluating the nourishing effects of Jisheng on the liver and kidney, both methanol-extracted TL and YC were used in the present study to treat alcohol (Et-OH)-induced damages of the rat liver and kidney. From the biochemical and pharmacological results, both the TL and YC extracts have the protection effects on the liver and kidney. Pathological results also revealed that both the extracts could decrease the Et-OH-induced liver inflammation, stagnant blood and necrosis. These results are in consistent with the biochemical indexes of serum. The function of dispelling the free radical [H2O2] is one of the mechanisms that Jisheng possessed protecting the liver and kidney.