虎杖提取物白藜蘆醇對Friend型鼠愛滋病毒作用的實驗研究

The Experiment Study of anti-FLV Virus Effect of Resveratrol

洪志哲(Chih-Che Hung)唐明增(Ming-Zeng Tang) ； 楊子峰(Zi-Feng Yang) ； 李向陽(Xiang-Yang Li) ； 王新華(Xin-Hua Wang) ； 朱宇同(Yu-Tong Zhu)

《臺灣中醫醫學雜誌》 4卷1期 (2005/03) Pp. 74-82

https://doi.org/10.30032/TJCM.200503.0005

摘要

目的：透過體內實驗來研究由虎杖提取出的白藜蘆醇(Resveratrol，RES)成分對鼠愛滋病毒的治療作用。方法：以Friend型鼠愛滋病毒(FLV)腹腔接種於BALB/C小鼠，觀察白藜蘆醇對病毒感染鼠的脾指數、脾指數抑制率、胸腺指數及血液常規等指標的影響。結果：白藜蘆醇20mg/kg灌胃，對Friend型鼠愛滋病毒引起的小鼠脾腫大有明顯的抑制作用，並能改善病毒引起的小鼠胸腺萎縮和血液常規指標的異常變化。結論：白藜蘆醇可減輕Friend型鼠愛滋病毒引起的脾腫大和胸腺萎縮等症狀，據此認為白藜蘆醇可能是一種有希望治療HIV的天然藥物。

關鍵字

白藜蘆醇 ； 鼠愛滋病毒 ； 脾指數 ； 脾指數抑制率

並列摘要

Objective: To study anti-FLV virus effect of Resveratrol in vivo. Methods: In vivo' the BALB/C mice were inoculated the FLV (Friend leukemia virus), the influences on spleen and thymus index, spleen inhibitive index rate of mice infected by FLV were observed in the mice infected with virus from intraperitoneal injection. Results: The experiment in vivo showed that Resveratrol at the concentration of 20mg/kg for the intranasal treatment markedly inhibited the splenomegaly caused by the infection of FLV and improved the atrophy of thymus gland and the abnormality of blood WBC and RBC caused by the inoculation of FLY. Conclusion: Resveratrol improved the symptom of mice splenomegaly and atrophy of thymus gland caused by FLV. Based upon the results, it appears that Resveratrol may be valuable in treating HIV as a natural product.

並列關鍵字

Resveratrol ； Friend leukemia virus ； spleen and thymus index ； spleen inhibitive index rate