COVID-19感染或疫苗注射後對月經的影響之中西醫文獻回顧及病例報告

The Impact of COVID-19 Infection or Vaccination on Menstruation: Chinese and Western Medicine Literature Review and Case Report

鄭伃婷(Cheng Yu-Ting) ； 吳炫璋(Wu Hsien-Chang) ； 許雅婷(Hsu Ya-Ting)

《中醫婦科醫學雜誌》 30卷2期 (2023/12) Pp. 43-51

https://doi.org/10.30030/JTCGM.202312_30(2).0005

摘要

COVID-19感染或疫苗注射後對月經及生育的機轉尚不明確，文獻回顧以現代研究新型冠狀病毒對女性生殖軸的影響，結合中醫對「血室」及「腦－心－肝－腎」情志軸的概念，探討COVID-19與女性月經及生育能力的關聯。病例報告為一位42歲女性，在施打COVID-19疫苗後出現閉經，並診斷為早發性停經，需要長期服用荷爾蒙藥物，以熱入血室及情志軸切入，改善不適症狀，提升生活品質。

關鍵字

新冠肺炎 ； 疫苗 ； 早發性停經 ； 熱入血室 ； 生殖軸

並列摘要

The mechanism of COVID-19 infection or vaccination on menstruation and fertility remain unclear. This literature review combines modern research on coronavirus impact on the female reproductive axis with the concepts of "Blood Chamber" and the "Brain-Heart-Liver-Kidney" emotional axis in traditional Chinese medicine to explore the association between COVID-19 and female menstruation and fertility. A case report is a 42-year-old woman had amenorrhea after receiving the COVID-19 vaccine and was diagnosed with premature menopause. She required long-term hormone therapy. Treatment with the concept of "heat in the Blood Chamber" and the emotional axis to alleviate discomfort symptoms and enhance quality of life.

並列關鍵字

COVID-19 ； Vaccines ； Premature Menopause ； Heat entering the blood chamber ； Reproductive Axis

參考文獻

Yan Jing, Li Run-Qian, Wang Hao-Ran, et al.: Potential influence of COVID-19/ACE2 on the female reproductive system. Molecular Human Reproduction 2020；26：367-373。

Alison Edelman, Emily R Boniface, Victoria Male, et al.: Association between menstrual cycle length and covid-19 vaccination: global, retrospective cohort study of prospectively collected data. BMJ Medicine 2022；1:e000297：1-10。

黃夢琪、施勇、彭丹紅：南京市育齡期女性感染新型冠狀病毒後月經相關改變的研究。Electronic Journal of Practical Gynecological Endocrinology 2023；10：16-19。

Kezhen Li, Ge Chen, Hongyan Hou, et al.: Analysis of sex hormones and menstruation in COVID-19 women of childbearing age. Reproductive BioMedicine Online 2021；42：260-267。

Paolo Facondo, Virginia Maltese, Andrea Delbarba, et al.: Case Report: Hypothalamic Amenorrhea Following COVID-19 Infection and Review of Literatures. Frontiers in Endocrinology 2022；13：840749。