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Biological Monitoring of Aflatoxin Exposures among Junior High School Students in Taiwan




黃麴毒素 肝癌 尿液測定

Parallel abstracts

In order to assess aflatoxin exposure among residents in Taiwan where hepatitis B virus infection and hepatocellular carcinoma are hyperendemic, a total of 501 junior high school students were recruited from 20 townships and precincts. Overnight urine samples were collected from study subjects and analyzed for the presence of aflatoxins by an enzyme-linked immunosorbent assay. The overall aflatoxin positive rate was 10.6%. Based on multiple logistic regression analysis, the aflatoxin positive rate was significantly associated with the season of sample collection. urbanizational level, and age-adjusted liver cancer mortality of residential area, and intake of peanut products, including shelled peanut, peanut butter, peanut powder or peanut candy. Urine samples collected in April and May had a higher positive rate than those collected in January and March with an odds ratio of 1.9 (P=0.03); the positive rate was also higher in areas of higher liver cancer mortality than in areas of low liver cancer mortality with an odds ratio of 2.1(P=0.07); the positive rate was also higher in areas of moderate urbanizational level than in areas of high or low urbanizational levels with an odds ratio of 2.2 (p=0.01); intake of any peanut products including shelled peanut , peanut butter, peanut powder or peanut candy had an odds ratio of 2.7(P=0.001). Although questionnaire interview may be useful to estimate roughly aflatoxin exposure, cautions have to be paid on seasonal variation, intra- or inter-individual variability, and varieties and sources of food items. It is necessary to conduct the biologic monitoring to assess aflatoxin exposure and its metabolism at the individual level.