並列摘要
Aspirin sensitivity, asthma, and chronic sinusitis with polyposis comprise aspirin triad syndrome. Aspirin sensitivity is determined by a patient history of significant nasal and bronchial symptoms after ingesting aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). The pathological mecha-nism in aspirin intolerance is through the inhibition of the cyclo-oxygenase pathway of arachidonic metabolism, which results in increased production of leukotrienes and thus causes bronchospasm. Aspirin triad has been widely reported in America and Europe but rarely in Taiwan. We encoun-tered two patients with aspirin triad. They complained of purulent rhinor-rhea, aspirin intolerance, asthma, and nasal obstruction. Both of them underwent functional endoscopic sinus surgery (FESS) for the treatment of sinus diseases with removal of nasal polyps. The symptoms of asthma and sinusitis with polyposis then improved without recurrence.