Acute epiglottitis complicated by bilateral thoracic empyema is a rare condition which may lead to a grave outcome. The possible sequence of spread of infection is from the supraglottic structure, through the retropharyngeal lymph nodes, to the mediastinum and bilateral pleural cavities. We herein present a 58-year-old healthy woman who suffered from acute epiglottitis. Dyspnea appeared 10 days after the onset of sore throat. Decreased breath sounds were noted after admission and chest X-ray demonstrated bilat-eral pleural effusion. A chest tap revealed bilateral pleural effusion with foul greenish discharge. The bacteriology of the pleural effusion was the same as that of epiglottic pus, i.e. Proteus vulgaris and Klebsiella pneumoniae. The patient died one month later due to gastrointestinal bleeding despite intense open drainage and medical treatment. We conclude that acute epiglottitis can be complicated not only by upper airway obstruction but also by mediastinitis and thoracic empyema, which can be detected by chest ausculta-tion and X-ray examination, especially in patients with a prolonged course.