Actinomycosis is a chronic suppurative bacterial infection. It most commonly affects the cervicofacial area, typically presenting as a soft tissue swelling and fistula with “sulfur granules” often seen in a purulent discharge. Culture of the organism is often difficult. With the general use of antibiotic, this disease has become a rare medical entity. We report a case of cervicofacial actinomycosis in a 73-year-old diabetic patient. His initial presentation was left cheek swelling, which was not responding to an empirical antibiotic therapy. “Sulfur granules” were identified in the draining discharge and bacterial culture confirmed the diagnosis of actinomycosis. His disease was cured after a surgical drainage followed by amoxicillin therapy. We conclude that a cervicofacial swelling not respond-ing to. an ordinary antibiotic therapy should raise the suspicion of actinomycosis, and a careful anaerobic culturing procedure is necessary for obtaining positive cultures.