- 期刊
手術刀、銣雅克雷射與二氧化碳雷射對鼠舌部切割及傷口癒合的影響
Effects of Scalpel、Nd-YAG Laser and GO2 Laser on Wound Healing of the Rat Tongue
摘要
在口腔疾病而言，使用二氧化碳（CO2）雷射與銣雅克（Nd-YAG）雷射均有臨床治療效果極佳的文獻報告，但未見在同一傷口之癒合比較，因此，我們同時使用二氧化碳雷射及銣雅克雷射，在老鼠口腔舌部產生切額傷口後，比較觀察傷口癒合的情形，並以手術刀造成的傷口癒合做一參考比較。 本研究採用Sprague-Dawley成熟雄性老鼠72隻，分成2組；1）為實驗A組：使用手術刀及二氧化碳雷射在老鼠舌頭兩側分別造成一直線狀傷口。2）為實驗B組：使用二氧化碳雷射及銣雅克雷射，亦在老鼠舌頭兩側分鄂造成直線狀傷口，上述老鼠分鄂在術後2小時、2天、7天、11天、28天時犧性，加以研究，分析做（Ⅰ）組織切片（Ⅱ）電子顯大鏡檢查。 研究所獲得結果顯示：1）刀切額傷口癒合最快。2）雷射傷口流血較少。3）Nd-YAG電射對於深廣熱效應最大，破壞週邊及組織也最強。4)二種雷射對組織的傷害不會造成不可逆、永久性的壞。
並列摘要
In the field of Otolaryngology, CO2 laser has been proven to be an effective tool in the treatment of various lesions. Nd-YAG laser is also recommended by some surgeons. For the comparative convenience between CO2 laser and Nd-YAG laser, our studies were designed to: 1)observe and compare the differences of healing process of the rat tongue wounds which were made by the scalpel, CO2 laser and Nd-YAG laser. 2)compare the healing rate of the tongue wounds by Nd-YAG laser and CO2 laser. 3)evaluate the inflammatory cell numbers during the healing process of wounds which were made by these 3 tools. The rats were sacrified at the same inter-val and the histological examinations were carried out. Seventy-two adult male Sprque-Dawley rats were grouped into two categories: 1)rats with scalpel incision on one side and CO2 laser on the other side of the tongue; 2)rats with the tongue incisions by using CO2 laser and Nd-YAG laser respecitively. The rats were sacrified on 2nd hr, 2nd, 7th, 11th, 14th and 28th days after surgery. The histological and electromicrosco-pical examinations to evaluate the wound healing of the rat tongues were performed. Comparing the effects of these 3 methods with each other, we found that scalpel wound had the most rapid healing process, CO2 laser incision got relatively less blood loss and Nd-YAG resulted in the most extensive tissue damage which was usually reversible.