This paper presents a readout circuit design and specific pressure system applications for silicon-based resistive type micro sensor in CMOS technology. Integrating with readout circuit, micro-controller AT89C51 and A/D converter, the sensor has been used to develop a generic, portable multi-purpose pressure meter. By interfacing with Si micro sensor, parts of commercial blood pressure meter, personal computer and virtual instrument LabVIEW, a prototype of blood pressure system has been realized for long-term monitoring usage. The measured range of generic pressure meter is from -291 to 100mmHg, and the accuracy is 5mmHg. The average sensitivity of blood pressure system is 0.041/-0.075 for systolic/diastolic measurements, and the accuracy is 1mmHg. The research extends the values of silicon pressure sensor for consumer and biomedical instrumental applications.