- 期刊
Eradication of Helicobacter Pylori with Omeprazole-Amoxicillin Combination Therapy Versus Famotidine a Randomized, Controlled Study
比較以Omeprazole-Amoxicillin合併療法或Famotidine根除幽門螺旋稈菌之效果
摘要
To assess the efficacy of low dose omeprazole combined with amoxicillin on the eradication of Helicobacter pylon and on healing as well as recurrence of ulcer in patients with duodenal ulcer disease, 100 consecutive patients with duodenal ulcer proven endoscopically and Helicobacter pylon colonization, confirmed by histological examination and rapid urease test, were randomly assigned to receive either famotidine 20 mg twice daily for eight weeks (group I, n=50) or omeprazole 20 mg once daily plus amoxicillin 500 mg four times daily over two weeks , followed by omeprazole 20 mg once daily for another two weeks (group Ⅱ, n=50). Endoscopy was performed prior to treatment and at three, six, and 12 months after treatment. All of the studied patients completed the treatment course; however, four patients of group I and two of group Ⅱ would not receive panendoscopy at three months after treatment and were withdrawn from the study. The eradication rate of Helicobacter pylon checked at three months after treatment was 0% (0/46) for group land 79% (38/48) for group Ⅱ, respectively (p＜0.0001). The ulcer healing rate was 87% (40/46) for group I and 96% (46/48) for group Ⅱ, respectively (p＞0.05). Among 38 patients in group I and 34 patients in group Ⅱ who were regularly followed up for more than 12 months, recurrence rate of duodenal ulcer was 68% (26/38) for group I and 6% (2/34) for group Ⅱ (p＜0.001) proven endoscopically at 12 months after treatment. It is concluded that combination therapy with a low dose of omeprazole and amoxicillin is safe, well-tolerated, and more effective for the eradication of Helicobacter pylon as compared with the treatment of famotidine and significantly reduces the relapse rate of duodenal ulcer.
並列摘要
To assess the efficacy of low dose omeprazole combined with amoxicillin on the eradication of Helicobacter pylon and on healing as well as recurrence of ulcer in patients with duodenal ulcer disease, 100 consecutive patients with duodenal ulcer proven endoscopically and Helicobacter pylon colonization, confirmed by histological examination and rapid urease test, were randomly assigned to receive either famotidine 20 mg twice daily for eight weeks (group I, n=50) or omeprazole 20 mg once daily plus amoxicillin 500 mg four times daily over two weeks , followed by omeprazole 20 mg once daily for another two weeks (group Ⅱ, n=50). Endoscopy was performed prior to treatment and at three, six, and 12 months after treatment. All of the studied patients completed the treatment course; however, four patients of group I and two of group Ⅱ would not receive panendoscopy at three months after treatment and were withdrawn from the study. The eradication rate of Helicobacter pylon checked at three months after treatment was 0% (0/46) for group land 79% (38/48) for group Ⅱ, respectively (p＜0.0001). The ulcer healing rate was 87% (40/46) for group I and 96% (46/48) for group Ⅱ, respectively (p＞0.05). Among 38 patients in group I and 34 patients in group Ⅱ who were regularly followed up for more than 12 months, recurrence rate of duodenal ulcer was 68% (26/38) for group I and 6% (2/34) for group Ⅱ (p＜0.001) proven endoscopically at 12 months after treatment. It is concluded that combination therapy with a low dose of omeprazole and amoxicillin is safe, well-tolerated, and more effective for the eradication of Helicobacter pylon as compared with the treatment of famotidine and significantly reduces the relapse rate of duodenal ulcer.