- 期刊
A Comparison of Ranitidine between Cimetidine in the Short-Term Treatment of Duodenal Ulcer
Ranitidine與Cimetidine對十二指腸潰瘍之治療效果比較
摘要
本研究目的在比較Ranitidine與Cimetidine對中國人這活動性十二指腸潰瘍之短期治療效果。63名經內視鏡證實是活動性且只有一個潰瘍之病人。因年齡、性別不同而隨機分配在Cimetidine或Ranitidine組，29名病人接受口服Cimetidine 400mg早晚各一次，27名病人接受Ranitidine 300mg睡前口服一次，經過四個星期的治療，Cimetidine組有19名，有40%，Ranitidine組有25.9%的病人白天仍然疼痛,Cimetidine組有20%,Ranitidine組有17.2%的病人在夜間疼痛仍然持續,但兩組成間均不具統計上的差異,由研究的結果顯示Ranitidine在治療活動性十二指腸潰瘍及臨床症狀的改善之效果比Cimetidine效果稍佳,但無統計學上之意義。
並列摘要
This study is to compare the healing and pain relieving effect of cimetidine and ranitidine in the short-term treatment of active duodenal ulcer in Chinese patients. Sixty-three patients with endoscopically proved active, single ulcer were stratified by age and sex and then randomly assigned to either ranitidine or cimetidine group. Twenty-nine patients received cimetidine400mg twice daily and the second endoscopy showed healing in 19(65.6%) of them. Twenty-seven patients received ranitidine300mg at the bedtime and the second endoscopy showed healing in 21(80.8%). The difference was not statistically significant. The pain relieving effect was not different either. The proportion of patients with diurnal pain at the end of study was40.0%us25.9% and that with nocturnal pain was in 20.0%us17.2%, respectively for cimetidine and ranitidine group. This study showed that ranitidine was effective cimetidine in healing and relieving of the active duodenal ulcer.